NAD+ and the Mitochondrial Ledger
NAD+ is the coenzyme that keeps electron transport running. Levels decline with age — and the downstream effects are measurable.
Every ATP molecule your body produces depends on NAD+ shuttling electrons through the mitochondrial respiratory chain. It is also the required substrate for sirtuins and PARP enzymes governing DNA repair.
Why levels fall
NAD+ concentrations decline substantially between early adulthood and midlife as consumption by repair enzymes rises and salvage pathway efficiency drops. The consequence is a broad reduction in cellular repair bandwidth.
Route determines the curve
Injectable and IV routes bypass first-pass metabolism and produce sharp repletion; oral precursors are convenient but flatter. Neither is universally correct.
Methylation support
Because NAD+ metabolism consumes methyl groups, extended courses are paired with methyl donor monitoring and support.
Frequently asked
What does NAD+ feel like?
Most patients describe mental clarity and steady energy rather than stimulation. IV administration can cause transient flushing or chest tightness if infused too quickly.
How often is NAD+ dosed?
Protocols vary from a loading series to weekly maintenance, decided by your provider based on goals and response.
This article is educational and is not medical advice. Treatment decisions are made by a licensed provider after a clinical evaluation.
